Another characteristic attribute of PD is the buildupof abnormalprotein aggregates termed Lewy bodies in neurons of PD patients.58−62 Lewy bodies, considered a pathological hallmark of PD, primarilyconsist of misfolded α-synuclein protein and are found in variousbrain regions, including the substantia nigra and other structuresinvolved in motor and cognitive function. The gene discussed is SNCA; the disease is Parkinson disease.