Their findings revealed that all-grade colitis (OR 8.7, 95 % CI 5.8–12.9), hypophysitis (OR 6.5, 95 % CI 3.0–14.3) and rash (OR 2.0, 95 % CI 1.8–2.3) were more prevalent with CTLA-4 monoclonal antibodies. The gene discussed is CTLA4; the disease is hypophysitis.