The present systematic review and meta-analysis focused on five important VDR gene polymorphisms, including ApaI (rs7975232), BsmI (rs1544410), Cdx2 (rs11568820), FokI (rs22228570), and TaqI (rs731236), as well as the risk for the development of PCOS. The gene discussed is VDR; the disease is polycystic ovary syndrome.