VEGFA and neoplasm: EVs have already been shown to carry several proangiogenic factors, including VEGF, matrix metalloproteinases (MMPs), and their endogenous activator CD147, PDGF, microRNAs, and lncRNAs as well as up-regulating their expression in ECs [5,6], thus facilitating interactions between tumor and ECs or other cells involved in angiogenesis.