Future studies, including determining genotypic signatures in other carcinoma cell lines, investigating the functions of MMP13 and LAMB1 in Arhgap39-depleted cells, and establishing primary culture cells exhibiting oncogenic KrasG12D and defective p53, may ascertain our findings presented in Hepa1-6 and Hepa-1c1c7 cells. The gene discussed is TP53; the disease is carcinoma.