We further generated spontaneously developing hepatoma in mice to confirm whether the liver cancer cells isolated from Alb-Cre_KrasLSL-G12D_p53fl/fl_Arhgap39fl/fl (KPA) mice displayed more aggressive migration and invasion than the control cells from Alb-Cre_KrasLSL-G12D_p53fl/fl (KP) mice. The gene discussed is ALB; the disease is hepatocellular carcinoma.