ACSL4 and acute lymphoblastic leukemia: In addition, apigenin significantly decreased the levels of glutathione peroxidase 4 (GPX4) and solute carrier family 7-member 11 (SLC7A11), increased that of acyl-CoA synthetase long-chain family member 4 (ACSL4) expression in ALL cells, and those regulation trends were partially reversed by CC (Fig. 3E).