EMP2 and cancer: In BRCA, THCA, ESCA, and LIHC, EMP2 mRNA is significantly elevated compared to normal tissues; meanwhile, in KICH, LUAD, KIRP, PRAD, LUSC, and HNSC, EMP2 mRNA levels are markedly lower than in corresponding normal tissues, confirming previous reports and underscoring the complexity of EMP2’s role in cancer biology.