The anti-migratory activity exhibited by the extract and its fraction on colon adenocarcinoma cell lines was found to be higher than that observed by previous studies for the compounds thymol, kaempferol and wogonin.42 The phytoconstituents in petroleum ether fraction, 2,6-bis (3,4 methylenedioxyphenyl)-3,7- dioxabicyclo (3.3.0) octane can modulate the expression of cell cycle regulators and suppress the expression of eukaryotic translational initiation factor 4E (EIF4E). This evidence concerns the gene EIF4E and colon adenocarcinoma.