This mechanism is responsible for inhibition of expression of an ECM degrading enzyme, matrix metalloprotease-9 (MMP-9), thereby preventing cancer cell metastasis.41 Besides this, inhibition of nitric oxide synthase-2 (NOS2) expression by the phytochemicals of the petroleum ether fraction could also be one of the possible mechanisms involved in its anticancer property by preventing cancer cell migration.43 The gene discussed is NOS2; the disease is cancer.