COBLL1 and Lipedema: Studies have suggested a possible link between the lipedema phenotype and specific genes, such as the IL-6 (Interleukin-6) gene described by Di Renzo et al.37 and the LHFPL6 gene identified by Precone et al.38 Other studies, including those of Klimentidis et al.,39 have revealed significant associations between the genetic loci VEGFA and GRB14-COBLL1 and lipedema.