By comparing the ssGSEA scores of leukemic cell state signatures between groups dichotomized by mutation status, we observed numerous significant correlations, including TP53 enriched for leukemic_S1, GATA2 enriched for leukemic_S2, PML-RARA, a biomarker of French-American-British (FAB) M3 AML, correlating with leukemic_S3, and numerous other associations. The gene discussed is PML; the disease is acute myeloid leukemia.