Moreover, several mutations displayed strong correlations with multiple leukemic cell states simultaneously, such as FLT3-ITD (enriched for S2, S5, and S9), GATA2 (S2, S5, and S6), and RUNX1 (enriched for S5 and S9), suggesting that these AML tumors may incorporate features from multiple leukemic cell states (Fig. 3c; Supplementary Table S6). This evidence concerns the gene RUNX1 and acute myeloid leukemia.