These include key processes previously identified in pan-cancer analysis [20, 41, 42], such as proliferation and DNA replication (e.g. TUBA1B, STMN1, and TOP2A) in leukemic_S1, RNA splicing (e.g. LUC7L3, PNN, and DDX17) in leukemic_S2, epithelial-mesenchymal transition (EMT) and coagulation (e.g. VIM, ANXA1, and CRIP2) in leukemic_S7, and stress (e.g. FOS, JUN, and EGR1) in leukemic_S8. This evidence concerns the gene TOP2A and cancer.