Furthermore, to uncover the regulatory function of TRIM35 in EC‐SMC interaction during vascular remodeling, we examined ubiquitination‐related genes in the EC cluster, for ubiquitination plays a crucial role in endothelial dysfunction and is involved in the progression of a diverse diseases caused by endothelial impairment.[37] Interestingly, we found higher ubiquitination score of ECs after transplantation (Figure 1C). Here, TRIM35 is linked to endothelial dysfunction.