However, although STX6 appears to modify disease susceptibility,8 in more recent work, we showed no association with age of onset or disease progression49 and that knockout of Stx6 expression in mouse has no, or modest, effects on prion disease incubation time.50 In this work, we have shown increased STX6 expression was significantly linked to risk of sCJD across multiple reference panels, both for TWAS and PWAS, along with e/pQTL-GWAS colocalization, whereas evidence was limited for other genes (including KIAA1614) at the same locus. This evidence concerns the gene STX6 and prion disease.