In mice, PMA increased the formation of NETs and CD3(+)CD4(+)T cells number, decreased CD3(+)CD8(+)T cells number in tumour and perforin, granzyme A, granzyme B, IFNγ, and TNF‐α levels, and promoted LUAD growth and the number of lung tumour nodules, suggesting that PMA promoted NETs formation, inhibited CD8(+) T cells activity, and promoted LUAD growth. The gene discussed is PRF1; the disease is neoplasm.