BRAF mutations can be subclassified into three distinct classes: Class 1 mutants that occur at position V600 signal as constitutively active monomers and are the most common class in CRC; class 2 mutants that form RAS‐independent RAF dimers; and class 3 mutants that have low or no kinase activity but act by amplifying upstream signals in the MAPK pathway [8]. The gene discussed is BRAF; the disease is colorectal carcinoma.