In colon cancer, alterations in the PI3K pathway genes PIK3CA, PTEN, AKT1, and AKT2 were significantly overrepresented in the RAS/BRAF‐altered subgroup in comparison to the RAS/BRAF‐wt subgroup (P < 0.01, Fisher's exact test with Benjamini–Hochberg correction), only AKT3 alterations were not significantly overrepresented (P > 0.05, Fisher's exact test with Benjamini–Hochberg correction). This evidence concerns the gene PTEN and malignant colon neoplasm.