Currently, the widely used diagnostic test algorithm for screening HIV infection employs fourth‐generation immunoassays, which simultaneously test for p24 antigen, a protein produced early during HIV infection, and immunoglobulin M (IgM) and IgG antibodies to HIV‐1 and HIV‐2 [4], followed by the Bio‐Rad Geenius assay for HIV‐1 and HIV‐2 differentiation [5]. This evidence concerns the gene CD40LG and HIV infectious disease.