We were interested to study the effect of Dapagliflozin and Dapagliflozin-Saxagliptin combination groups on podocyte health by quantifying the exosome expression for Nephrin, Renal Wilm’s Tumor (WT-1) and Podocalyxin like protein 1( PODXL) in urine samples. This evidence concerns the gene NPHS1 and kidney Wilms tumor.