The enhanced phagocytic capacity of placental macrophages in early- and late-onset preeclampsia, along with their elevated secretions of MMP9 and anti-inflammatory cytokines IL4, IL13, and TGFβ, indicate their adaptive role and plasticity in managing inflammation and maintaining tissue homeostasis [114], which can be understood as a compensatory effect on preeclampsia. This evidence concerns the gene MMP9 and preeclampsia.