AKT1 and cancer: The DEGs identified from the analysis of two datasets (TCGA-HNSC, GEO dataset, and whole transcriptomic data) using the pathway activity module of GSCALite showed activation or inhibition of various pathways related to apoptosis, the cell cycle, DNA damage response, hormone ER, hormone AR, EMT, PI3K/AKT, RAS/MAPK, RTK etc., across 32 different cancers.