Further investigation of tumor progression in the DLP, shown to resemble human prostate peripheral zone where most adenocarcinoma develop [33], revealed that Pten/Trp53(i)pe−/− mice present more invasive adenocarcinoma than Pten(i)pe−/− mice, as well as cell infiltrates in the liver at a 50% penetrance. This evidence concerns the gene TP53 and adenocarcinoma.