PTEN and ductal breast carcinoma in situ: Between 5 and 7 months AGI, all Pten(i)pe−/− and Pten/Trp53(i)pe−/− mice harbored PINs and intraductal carcinoma (IDC) within the DLPs, but invasive tumors were twice more frequent in Pten/Trp53(i)pe−/− mice (Fig. 2A, B).