TP53 and neoplasm: As senescent cells secrete a cocktail of cytokines, chemokines, growth factors and matrix-remodeling factors, termed senescence-associated secretory phenotype (SASP), that might remodel their immune microenvironment and impact tumor progression [23], we immunophenotyped the prostates of control, Pten(i)pe−/− and Pten/Trp53(i)pe−/− mice 5 months AGI by flow cytometry.