PTEN and prostate adenocarcinoma: The signature of these cells, defined as globally distinguishing genes of this cluster that are upregulated in transcriptomes of tumors of the TCGA PRAD cohort (Fig. 3C, see “Methods”), was not detected in epithelial cells of Pten(i)pe−/− mice 3, 6 or 9 months AGI [12] (Supplementary Fig. 4C).