KHDRBS1 and nonpapillary renal cell carcinoma: In conclusion, our findings demonstrate that the lncRNA-encoded protein TPM3P9 interacts with the RNA-binding protein RBM4 to inhibit exon skipping of TCF7L2, thereby increasing the expression of the TCF7L2-L variant, which promotes ccRCC cell proliferation through cooperation with SAM68 to transcriptionally upregulate RELB.