TPM3P9 was found to interact with the splicing factor RBM4 to upregulate the oncogenic splice variant TCF7L2-L, which associates with SAM68 to transcriptionally induce RELB expression, thereby activating NF-κB signaling in ccRCC cells (Fig. 9). This evidence concerns the gene TCF7L2 and nonpapillary renal cell carcinoma.