On the other hand, by activating several pathways in breast cancer cells, including the JNK pathway, chemotherapy stimulated the secretion of different matrix proteins (i.e., osteopontin, tenascin C, the B-lymphoma Mo-MLV insertion region 1, and phosphatase and tensin homolog), thereby facilitating breast cancer progression and chemoresistance [83]. The gene discussed is PTEN; the disease is breast carcinoma.