KDR and breast carcinoma: Other authors have demonstrated that DHA reduced the expression of HIF-1α and several angiogenic factors, including TGF-β, Snail-1 and -2, and vascular endothelial growth factor receptor (VEGFR) in MDA-MB-231 and BT-474 breast cancer cells and in EVs derived from these lines under hypoxic conditions, suggesting that DHA can inhibit breast cancer progression, also inducing anti-angiogenic effects [114].