Based on the univariate and multivariate Cox regression analyses, the EV p75NTR was demonstrated to be an independent prognostic factor (log-rank p-value = 0.004) after considering age, gender, tumour stage, grading, resection margin, neoadjuvant therapy, lymphatic invasion, venous invasion and Pn status (Table 1), suggesting that plasma-derived EV p75NTR may be used for risk stratification to predict the prognosis of PDAC patients. The gene discussed is NGFR; the disease is neoplasm.