With the help of murine pancreatic cancer cell model [14], murine SCs (mSCs) were found to be dedifferentiated when confronted to neuroinvasive cancer cells compared to non-neuroinvasive cancer cells, as indicated by the upregulation of p75 neurotrophin receptor (p75NTR/NGFR) expression levels, which has been shown to play a vital role in mediating neuronal signalling and NI [7, 15, 16]. Here, NGFR is linked to familial pancreatic carcinoma.