Thus, in our study, it is conceivable that pancreatic cancer cells secrete p75NTR in the EVs that can be transferred to SCs following EV uptake, leading to increased levels of p75NTR in the SCs by promoting their dedifferentiation, thereby activating downstream p75NTR signalling and facilitating cancer cell invasion into nerves. The gene discussed is NGFR; the disease is familial pancreatic carcinoma.