SERPINF1 and Insulin resistance: Therefore, our present study suggests that baseline PEDF level is a more sensitive biomarker of insulin resistance than other well-known parameters of insulin resistance and/or central obesity, such as fasting IRI, waist circumference, HOMA-IR, or VAT area, and could predict which T2DM patients’ amygdalar metabolic activity was effectively decreased by add-on OHAs therapy.