In addition, siRNA-mediated silencing of Drp1 in MEFs and in human H441 and A549 non-small cell lung cancer (NSCLC) cell lines reproduced this effect when undergoing ferroptosis induced by RSL3, erastin or buthionine sulfoximine—an irreversible inhibitor of γ-glutamylcysteine synthetase that causes GSH depletion (Fig. 2E, F, Fig. S2D–I). The gene discussed is DNM1L; the disease is non-small cell lung carcinoma.