Consistently, target genes positively regulated by p63 and affected in AEC syndrome, including Krt14, Krt5, Dsp and Dsg1, were induced in mutant keratinocytes treated with Epi confirming that transcriptional function of p63 may be at least partially recovered by decreasing protein aggregation by treatment with the compound. Here, DSP is linked to Ankyloblepharon - ectodermal defects - cleft lip/palate.