Notable examples include WLS, which exhibits high expression levels in chronic neuropathic pain patients23; RWDD3, which is downregulated after sciatic nerve ligation24; Netrin-3 (NTN3), whose reduced expression is strongly associated with the severity of diabetic neuropathic pain in a diabetic mouse model25; and HNMT which has been linked to the morphine dosage requirements in cancer pain patients.26 The gene discussed is NTN3; the disease is cancer.