Risk score = 1 – 0.994 exp(0.90βX), where βX= 0.0096984 * age in years at first primary-care prescription − 0.3190717 * female sex + 0.0259328 * Body Mass Index + 0.320509 * low alcohol intake + 0.0962384 * moderate alcohol intake + 0.8169186 * hazardous alcohol intake + 0.7002583 * ex-alcohol intake + 0.2276251 * diabetes + 1.09148 * chronic kidney disease stage 3 + 0.2938861 * ACE inhibitors + 0.2653679 * aspirin + 0.1298207 * NSAIDs. The gene discussed is ACE; the disease is chronic kidney disease.