MAPT and Alzheimer disease: Collectively, these diverse senescent cell populations are implicated in numerous pathologic features of AD and AD-related dementias, including neuroinflammation/gliosis,94,95,98,100 neuronal loss,95,97 pathologic tau,95,97 Aβ,100 mitochondrial dysfunction,97 impaired BBB integrity,101 and aberrant cerebral blood flow.97