MAPT and Cognitive impairment: Endogenous tau clusters86,153 and increased phosphorylated tau staining71 have been reported in the hippocampus and entorhinal cortex of cisplatin-treated B6 mice with cognitive deficits; in these studies, therapeutic interventions, including administration of mesenchymal stem cells153 and a histone deacetylase 6 inhibitor,71 prevented tau pathology and rescued cognitive deficits.