TRK inhibitors, which target TrkB among other Trks, are being used to treat cancers with neurotrophic Trk (NTRK) fusions.] Additional studies are needed to characterize the contribution of BDNF signaling121 in mediating the neuroprotective effect of gamma entrainment using sensory stimuli (GENUS)122 and to determine if adenosine signaling can be selectively modulated to increase cognitively beneficial BDNF expression.123. The gene discussed is BDNF; the disease is cancer.