Many EMT-associated transcription factors (TFs), such as Zeb1, Twist, Snail, and Slug, along with EMT-inducing signaling pathways like transforming growth factor-beta (TGF-β) and Wnt, have been shown to play an essential role in promoting drug resistance in cancer cells (Ashrafizadeh et al., 2024; Ebrahimi et al., 2024; Guo et al., 2024; Xue et al., 2024). The gene discussed is SNAI1; the disease is cancer.