Interestingly, the related P4-ATPase, ATP11A, which also translocates PS across membranes (74), appears to preferentially immunoprecipitate NUMB Ex9in from the pancreatic cancer cell lines PANC-1 and SW1990 (75) eluding to differential roles for NUMB isoforms. The gene discussed is NUMB; the disease is pancreatic neoplasm.