Uncovering a new molecular pathway involving the regulation of PTEN by PHLPP1 and the HUR/Jun D/miR-613/NCL axis, which has not been widely explored in the context of tobacco-related lung carcinogenesis; 2), Prior studies have explored the individual roles of PHLPP1 and PTEN in cancer, including their downregulation in response to carcinogenic factors. The gene discussed is NUCLEOLIN; the disease is cancer.