As we had previously confirmed in preclinical breast cancer models [14], Cx3cl1 also attracted more F4/80-positive macrophages to the tumour microenvironment in the ID8-Trp53-/- model (median 68 % (Cx3cl1+) vs. 55 % (Control) of total cells, P = 0.017; Fig. 3F). The gene discussed is CX3CL1; the disease is breast cancer.