However, (1) we see only a small proportion of tumor-promoting M2 macrophages, which remains unchanged by CX3CL1, (2) we fail to reproduce macrophage recruitment in athmic nude mice despite having significantly poorer survival, and (3) work by other groups showed that macrophage inhibition in the ID8 model tends to accelerate tumour growth, matching our observation of an increased macrophage infiltration by CX3CL1 [27]. This evidence concerns the gene CX3CL1 and neoplasm.