NR1H3 and fatty liver disease: Yang et al. (2023) treated ginkgo biloba extract to laying hens with FLHS, and the expression level of LXRα was significantly down-regulated in the treatment group. One study even indicated that overexpression of the miR-216/miR-217 cluster or reduction in TM9SF3 levels led to activation of the proliferator-activated receptor/sterol regulatory-element binding protein (PPAR/SREBP) pathway, thereby alleviating fatty liver in laying hens(Zhu et al., 2022).