α6 integrin-laminin interactions for abluminal passage of ALL cells between the skull bone marrow and subarachnoid CSF.20 In this regard, it is noteworthy that laminin staining was intense around the ACE points,43 and the authors proposed that laminin and α6 integrin interactions are pivotal for trafficking cells, including myeloid cells, to the subarachnoid space at ACE points. The gene discussed is LAMB2; the disease is acute lymphoblastic leukemia.