In T-ALL, oxidative phosphorylation (OxPhos) is a critical pathway for leukemia cell survival,35 and there is a direct relationship between NOTCH1, elevated OxPhos gene expression, and acquired chemoresistance in pre-leukemic and leukemic models.36 Additionally, ETP-ALL exhibits distinctive regulation of ATP synthesis coupled with electron transport and OxPhos,37 suggesting that targeting OxPhos offers a potential therapeutic direction for T-ALL. This evidence concerns the gene NOTCH1 and leukemia.