IKZF1 acts as a tumor suppressor in T-ALL,23,24 and haploinsufficiency stemming from gene mutations leads to an unfavorable prognosis in T-ALL patients.25 In our study, we have shown that CX-4945 can restore the repressive function of IKZF1 as a transcriptional regulator of BCL-2. This evidence concerns the gene BCL2 and acute lymphoblastic leukemia.