In order to ascertain whether the increased values in s-Endocan or s-VCAM-1 were mainly due to hypertension or to previous treatment with RAAS inhibitors, we compared s-Endocan and s-VCAM-1 values in COVID-19 hypertensive patients previously treated with RAAS inhibitors and COVID-19 hypertensive patients not previously treated with RAAS inhibitors. This evidence concerns the gene VCAM1 and hypertensive disorder.