SELE and COVID-19: On the other hand, s-E-Selectin, another endothelial adhesion molecule, was higher in critical on VV-ECMO patients at admission, remaining elevated in this group and significantly increasing its concentration in the other critical COVID-19 group throughout hospitalization, which also corroborates the previously reported association of E-Selectin with severity and mortality in COVID-19 patients [31, 33].