According to Börnhorst et al. [10] and based on the patterns derived above, multivariate mixed-effects models were used to assess the age-dependent associations of modifiable and non-modifiable risk factors as well as C-reactive protein (CRP), with the log-transformed probabilities of developing abdominal obesity, hypertension, dyslipidemia, or several metabolic disturbances relative to the probability of staying metabolically healthy, with the latter serving as the reference group. The gene discussed is CRP; the disease is hypertensive disorder.