HTR2A and treatment resistant depression: Its mechanism involves serotonin receptor activation, chiefly at 5-HT2A, leading to swift changes in consciousness and profound visual and emotional experiences.35 Ayahuasca’s therapeutic and spiritual potential, particularly for TRD, has garnered rising international attention.36,37 This study found that ayahuasca significantly reduced depressive symptoms, decreasing the MADRS score by 25.6 points, which corresponds to a 77% reduction from baseline levels.