BRCA1 and familial pancreatic carcinoma: Loss‐of‐function alterations in BRCA1 and/or BRCA2 genes impair repair of DNA double‐strand breaks, leading to genomic instability and malignant transformation; germline BRCA1‐2 pathogenic variants (gBRCA1‐2pv) are indeed associated with increased risk of developing ovarian, breast, prostate, and pancreatic cancers [4, 5, 6].