A four-gene blood signature that includes ISG15, IL16, 2′,5′-Oligoadenylate Synthetase Like (OASL), and Adhesion G protein-coupled Receptor E5 (ADGRE5) yielded an AUC of over 0.90 in distinguishing various viral infections from non-viral conditions [32]. Here, OASL is linked to viral infectious disease.