Viperin plays a crucial role in the innate immune response to viral infections, restricting the replication of a broad spectrum of viruses, including human cytomegalovirus (HCMV), herpes virus 8 (HHV-8), Kaposi’s sarcoma-associated herpesvirus (KSHV), human immunodeficiency virus 1 (HIV-1), influenza A virus (IAV), hepatitis C virus (HCV), dengue virus (DENV), tick-borne encephalitis virus (TBEV), Zika virus (ZIKV), West Nile virus (WNV), and chikungunya virus (CHIKV), as previously reviewed [63]. This evidence concerns the gene RSAD2 and viral infectious disease.