The critical COVID-19 group showed, respectively, 338% and 409% higher values of IL-8 (p = 0.0030; p = 0.0002) in relation to the moderate and severe COVID-19 groups, 115% and 145% of IL-10 (p = 0.0191; p = 0.0012), 187% and 228% of TNF-α (p = 0.0022; p < 0.001), 99% and 106% of IFN-α (p = 0.0020; p = 0.0002), and 236% and 186% of IL-1β (p = 0.0060; p = 0.0093). The gene discussed is IL1B; the disease is COVID-19.