The abundance of TRIM56 is modestly upregulated by viral infections and a variety of stimuli mimicking viral infection settings, including the dsRNA surrogate poly(I:C) and type I IFNs, indicating that TRIM56 is an IFN-stimulated gene (ISG), albeit only moderately IFN-inducible [28,31,35]. The gene discussed is TRIM56; the disease is viral infectious disease.