The screening of 62 antiviral sensor RBPs in HEK293T cells by the co-transfection of the corresponding RBP-encoding plasmids and the pNL4.3 plasmid revealed a 20-fold reduction in the infection of TZM-bl reporter cells by viral particles from cells transfected with the NEDD4-binding protein 1 (N4BP1) construct. The gene discussed is N4BP1; the disease is infection.