When some of these proteins were validated by a dual-fluorescent reporter virus (DuoFluo, R7GEmTB) infection in knockdown Jurkat cells, all thirteen proteins were involved in either latent (TOP2A, SRP14, HNRNPH1, DDX1, and HNRNPL) or productive infection (FLNA, HMGB3, PTBP1, HSP90AA1, and KIF2C), with SRP1 knockdown decreasing splicing while HMGB3 and PTBP1 increased it. The gene discussed is HMGB3; the disease is infection.