The allelic frequencies of SNPs in the coding genes tlr8 (1), tlr8 (2), tlr7, tlr3, tirap, and mcp1 were calculated for the population of hospitalized children with COVID-19 and compared with global databases such as Global ALFA, Global 1000 genomes, and Global gnomAD, as well as databases with populations with genotypes closer to South America, such as Americana 1000 Genomes and Americana genomAD (dbSNP (https://www.ncbi.nlm.nih.gov/snp/, accessed on 15 July 2024). This evidence concerns the gene TLR7 and COVID-19.