The allelic frequency of SNPs in the coding genes tlr8 (1), tlr8 (2), tlr7, tlr3, tirap, and mcp1 was calculated for the population of hospitalized children with COVID-19 and compared with global databases such as Global ALFA, Global 1000 Genomes, and Global gnomAD, as well as databases with populations more closely related to South America, such as Americana 1000 Genomes and Americana gnomAD. This evidence concerns the gene CCL2 and COVID-19.