Detectable HBV DNA plus ALT >ULN orDetectable HBV DNA regardless of ALT level, who meet any of the following criteria:Family history of cirrhosis or HCCAge of at least 30 yearsEvidence of significant liver inflammation (Grade ≥ 2) or fibrosis (Stage ≥ 2)Presence of extrahepatic manifestations related to HBV infection. This evidence concerns the gene GPT and Cirrhosis.