Significant fibrosis, regardless of ALT or HBV DNA orHBV DNA > 2000 IU/mL + ALT > ULN orThe presence of any one of the following criteria: coinfection with other viruses, family history of liver cancer or cirrhosis, immunosuppression status, having comorbidities such as diabetes, MASLD, HBV extrahepatic manifestations. The gene discussed is GPT; the disease is liver cancer.