Since the transmembrane serine protease 2 (TMPRSS2) and angiotensin-converting enzyme 2 (ACE2) proteins are involved in SARS-CoV-2 viral entry [16], we investigated whether TMPRSS2 was elevated in the urine of COVID-19-positive participants compared to the urine of COVID-19-negative participants. This evidence concerns the gene ACE2 and COVID-19.