MMP2 and neoplasm: Nanocrystals of resveratrol using Pluronic F127 were obtained by the wet media milling technique, and the formulation showed better anticancer activity (inhibition of tumor growth, total number of tumor cells, concentration of NO and arginase activity, increased percentages of active macrophages) and antiangiogenic activity (inhibition of VEGF and metalloproteinases (MMP-2)) than the pure substance.