Possible mechanisms include the inhibition of the activity of phase-I-enzymes (CYPs), regulation the expression of nuclear factor erythroid 2–related factor 2 (Nrf2) and Nrf2 target genes, suppression of tumor cells’ growth, inhibition of angiogenesis by the regulation of VEGF (vascular endothelial growth factor) and metastasis and reduction of the proliferative capacity of cancer cells by altering their metabolism [24]. The gene discussed is VEGFA; the disease is neoplasm.