Arg-Gly-Asp (RGD); chitosan; dopamine (DOPA); folic acid; hyaluronic acid; poly(ethylene glycol) (PEG); reticuloendothelial system (RES); transferrin (Tf); and vascular endothelial growth factor (VEGF) were loaded onto poly(lactic-co-glycolic acid) nanoparticles (NPs), demonstrating the passive and active tumor targeting capabilities of ligand-receptor interactions (Figure 1G) [66,67,68,69]. This evidence concerns the gene TF and neoplasm.