In cancerous cells, NF-κB is often constitutively activated, promoting the expression of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), interleukin-1β (IL-1β), and cyclooxygenase-2 (COX-2), which contribute to tumor growth and metastasis [19]. The gene discussed is NFKB1; the disease is neoplasm.