A decreased OAPT1B1 function because of the SLCO1B1 c.521T>C variant leads to increased systemic and reduced hepatic statin concentrations; it is strongly related to the risk of myopathy (odds ratio of 4.5 per copy of C allele), and—to a lesser extent—to the LDL-C-lowering effect [26]. The gene discussed is SLCO1B1; the disease is myopathy.